Also indexed as
PLP, Pyridoxal-5’-Phosphate, Pyridoxine
Introduction
Introduction
Vitamin B6 is the master vitamin for processing amino acids—the building blocks of all proteins and some hormones. Vitamin B6 helps to make and take apart many amino acids and is also needed to make the hormones, serotonin, melatonin, and dopamine.
Where is it found?
Potatoes, bananas, raisin bran cereal, lentils, liver, turkey, and tuna are all good sources of vitamin B6.
Vitamin B6 has been used in connection with the following conditions (refer to the individual health concern for complete information):
Science Ratings - Health Concerns
*** - Anemia (if deficient and for genetic vitamin B6-responsive anemia)
*** - Autism
*** - Depression (in women taking oral contraceptives)
*** - High homocysteine (in combination with folic acid and vitamin B12)
*** - Morning sickness
*** - Premenstrual syndrome
** - Age-related cognitive decline
** - Asthma
** - Canker sores
** - Carpal tunnel syndrome
** - Childhood intelligence (for deficiency)
** - Depression (associated with premenstrual syndrome)
** - Low back pain (in combination with vitamin B1 and vitamin B12)
** - MSG sensitivity
** - Pregnancy and postpartum support (if homocysteine levels are elevated)
** - Schizophrenia
** - Type 1 diabetes
** - Type 2 diabetes
** - Vertigo
* - Acne
* - Alcohol withdrawal support
* - Alzheimer’s disease (in combination with iron and coenzyme Q10)
* - Amenorrhea
* - Atherosclerosis
* - Attention deficit disorder
* - Celiac disease
* - Eating disorders (for bulimia)
* - Epilepsy
* - Fibrocystic breast disease
* - Heart attack
* - HIV support
* - Hypoglycemia
* - Kidney stones
* - Osgood-Schlatter disease (in combination with manganese and zinc)
* - Osteoporosis (to lower homocysteine)
* - Parkinson’s disease (with Sinemet® or Eldepryl®)
* - Photosensitivity
* - Pre- and post-surgery health
* - Preeclampsia
* - Seborrheic dermatitis
* - Sickle cell anemia
* - Stroke
* - Tardive dyskinesia
*** - Reliable and relatively consistent scientific data showing a substantial health benefit.
Where is it found?
Potatoes, bananas, raisin bran cereal, lentils, liver, turkey, and tuna are all good sources of vitamin B6.
Vitamin B6 has been used in connection with the following conditions (refer to the individual health concern for complete information):
Science Ratings - Health Concerns
*** - Anemia (if deficient and for genetic vitamin B6-responsive anemia)
*** - Autism
*** - Depression (in women taking oral contraceptives)
*** - High homocysteine (in combination with folic acid and vitamin B12)
*** - Morning sickness
*** - Premenstrual syndrome
** - Age-related cognitive decline
** - Asthma
** - Canker sores
** - Carpal tunnel syndrome
** - Childhood intelligence (for deficiency)
** - Depression (associated with premenstrual syndrome)
** - Low back pain (in combination with vitamin B1 and vitamin B12)
** - MSG sensitivity
** - Pregnancy and postpartum support (if homocysteine levels are elevated)
** - Schizophrenia
** - Type 1 diabetes
** - Type 2 diabetes
** - Vertigo
* - Acne
* - Alcohol withdrawal support
* - Alzheimer’s disease (in combination with iron and coenzyme Q10)
* - Amenorrhea
* - Atherosclerosis
* - Attention deficit disorder
* - Celiac disease
* - Eating disorders (for bulimia)
* - Epilepsy
* - Fibrocystic breast disease
* - Heart attack
* - HIV support
* - Hypoglycemia
* - Kidney stones
* - Osgood-Schlatter disease (in combination with manganese and zinc)
* - Osteoporosis (to lower homocysteine)
* - Parkinson’s disease (with Sinemet® or Eldepryl®)
* - Photosensitivity
* - Pre- and post-surgery health
* - Preeclampsia
* - Seborrheic dermatitis
* - Sickle cell anemia
* - Stroke
* - Tardive dyskinesia
*** - Reliable and relatively consistent scientific data showing a substantial health benefit.
** - Contradictory, insufficient, or preliminary studies suggesting a health benefit or minimal health benefit.
* - For an herb, supported by traditional use but minimal or no scientific evidence. For a supplement, little scientific support and/or minimal health benefit.
Who is likely to be deficient?
Vitamin B6 deficiencies are thought to be very rare. Vitamin B6 deficiency can cause impaired immunity, skin lesions, and mental confusion. A marginal deficiency sometimes occurs in alcoholics, patients with kidney failure, and women using oral contraceptives. Some doctors believe that most diets do not provide optimal amounts of this vitamin. People with kidney failure have an increased risk of vitamin B6 deficiency.1 Vitamin B6 has also been reported to be deficient in some people with chronic fatigue syndrome.2
How much is usually taken?
The most common supplemental intake is 10–25 mg per day. However, high amounts (100–200 mg per day or even more) may be recommended for certain conditions.
Are there any side effects or interactions?
Vitamin B6 is usually safe, at intakes up to 200 mg per day in adults.3 However, neurological side effects can sometimes occur at that level.4 Levels higher than 200 mg are more likely to cause such problems. Vitamin B6 toxicity can damage sensory nerves, leading to numbness in the hands and feet as well as difficulty walking. The National Academy of Sciences performed an analysis of vitamin B6 studies. They determined the safe upper limit for long-term use is 100 mg per day. However, under supervision of a healthcare professional, up to 200 mg per day of vitamin B6 can be safely taken by most men and nonpregnant women for limited periods of time. Pregnant and breast-feeding women should not take more than 100 mg of vitamin B6 per day without a doctor’s supervision.
Since vitamin B6 increases the bioavailability of magnesium, these nutrients are sometimes taken together.
Who is likely to be deficient?
Vitamin B6 deficiencies are thought to be very rare. Vitamin B6 deficiency can cause impaired immunity, skin lesions, and mental confusion. A marginal deficiency sometimes occurs in alcoholics, patients with kidney failure, and women using oral contraceptives. Some doctors believe that most diets do not provide optimal amounts of this vitamin. People with kidney failure have an increased risk of vitamin B6 deficiency.1 Vitamin B6 has also been reported to be deficient in some people with chronic fatigue syndrome.2
How much is usually taken?
The most common supplemental intake is 10–25 mg per day. However, high amounts (100–200 mg per day or even more) may be recommended for certain conditions.
Are there any side effects or interactions?
Vitamin B6 is usually safe, at intakes up to 200 mg per day in adults.3 However, neurological side effects can sometimes occur at that level.4 Levels higher than 200 mg are more likely to cause such problems. Vitamin B6 toxicity can damage sensory nerves, leading to numbness in the hands and feet as well as difficulty walking. The National Academy of Sciences performed an analysis of vitamin B6 studies. They determined the safe upper limit for long-term use is 100 mg per day. However, under supervision of a healthcare professional, up to 200 mg per day of vitamin B6 can be safely taken by most men and nonpregnant women for limited periods of time. Pregnant and breast-feeding women should not take more than 100 mg of vitamin B6 per day without a doctor’s supervision.
Since vitamin B6 increases the bioavailability of magnesium, these nutrients are sometimes taken together.
Drug Interactions
Certain medicines interact with vitamin B6: Some interactions may increase the need for vitamin B6 (+), other interactions may be negative (-) and indicate vitamin B6 should not be taken without first speaking with your physician or pharmacist, others may require further explanation (?). Refer to the individual drug article for specific details about an interaction.
Note: The following list only includes the generic or class name of a medicine. To find a specific brand name, use the Medicines index.
Anticonvulsants (+)
Carbidopa (?)
Carbidopa/Levodopa (?)
Cycloserine (+)
Docetaxel (+)
Erythromycin (+)
Estrogens (Combined) (+)
Fenofibrate (+)
Fluorouracil (+)
Folic Acid (+) (-)
Gabapentin (+)
Gentamicin (?)
Hydralazine (+)
Hydroxychloroquine (+)
Isoniazid (?)
Levodopa (+)
Mixed Amphetamines (+)
Neomycin (+)
Oral Contraceptives (+)
Oral Corticosteroids (+)
Penicillamine (+)
Phenelzine (+)
Phenobarbital (+) (-)
Risperidone (+)
Sulfamethoxazole (+)
Tetracycline (+)
Theophylline/Aminophylline (+)
Tricyclic Antidepressants (+)
Trimethoprim (+)
Valproic Acid (+)
Certain medicines interact with vitamin B6: Some interactions may increase the need for vitamin B6 (+), other interactions may be negative (-) and indicate vitamin B6 should not be taken without first speaking with your physician or pharmacist, others may require further explanation (?). Refer to the individual drug article for specific details about an interaction.
Note: The following list only includes the generic or class name of a medicine. To find a specific brand name, use the Medicines index.
Anticonvulsants (+)
Carbidopa (?)
Carbidopa/Levodopa (?)
Cycloserine (+)
Docetaxel (+)
Erythromycin (+)
Estrogens (Combined) (+)
Fenofibrate (+)
Fluorouracil (+)
Folic Acid (+) (-)
Gabapentin (+)
Gentamicin (?)
Hydralazine (+)
Hydroxychloroquine (+)
Isoniazid (?)
Levodopa (+)
Mixed Amphetamines (+)
Neomycin (+)
Oral Contraceptives (+)
Oral Corticosteroids (+)
Penicillamine (+)
Phenelzine (+)
Phenobarbital (+) (-)
Risperidone (+)
Sulfamethoxazole (+)
Tetracycline (+)
Theophylline/Aminophylline (+)
Tricyclic Antidepressants (+)
Trimethoprim (+)
Valproic Acid (+)
Source: www.cncahealth.com